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Treatment for Hypothyroidism/Underactive Thyroid 

Oroxine, Eutroxsig & Eltroxin  (synthetic T4/Levothyroxine)

Thyroxine (Oroxine/Eutroxsig/Eltroxin) is prescribed for patients who have had a total thyroidectomy or who suffer from an underactive thyroid gland, (hypothyroidism).  Also as a result of a hemi-thyroidectomy, radioactive iodine or due to hypothyroidism.
Oroxine/Eutroxsig/Eltroxin are synthetic forms of the hormone Levothyroxine (T4).  It is the closest form of thyroxine hormone to what a healthy thyroid gland produces.  Please read information regarding Oroxine/Eutroxsig and Eltroxin on the Treatments page of this website.

If the thyroid gland is underactive, your doctor will prescribe a small dose to start your treatment, usually 50 mcgs., and increase the dose as the thyroid gland becomes progressively inactive. If this medication is prescribed as a result of a total thyroidectomy, your treating doctor will determine the initial dose, after pathology tests.  It is unusual for patients to cease this medication once it has begun.

Please note:  Eltroxin is not the same formula as Oroxine and Eutroxsig.  Please read information regarding Oroxine, Eutroxsig and Eltroxin on the Treatments page of this website. 

Time to Take Levothyroxine Medication

Recent research supports The ATF’s Recommendation to take Oroxine/Eutroxsig first thing in the morning (as soon as your eyes are open) with a glass of water only, on an empty stomach.  Wait at least 30 – 60 minutes after taking the dose before breakfast.  Other medications, vitamins/minerals herbal medicines and supplements should not be taken at the same time to avoid interactions with Oroxine/Eutroxsig. An interval of at least  4 hours after taking Oroxine/Eutroxsig is recommended by Prof. Jim Stockigt before taking other medications. (Thyroid News No 7 Sept/Oct 2001). This is due to possible interactions and lower absorption.

Storage of Oroxine and Eutroxsig

It is essential to refrigerate blister strips not yet in use of Oroxine and Eutroxsig between 2 – 8 Degrees Celcius (refrigerated temperature).  The ATF Recommendation is to keep all of your tablets in the refrigerator, all of the time and go to the refrigerator in the morning to get your dose. This is to safeguard against spoilage from room temperatures rising throughout the day, due to seasonal change, or room heating during colder months.

Laboratory tests have shown that if not stored correctly, there is a reduction in potency of the active ingredient, thyroxine sodium.

Storage of Eltroxin

Eltroxin does not need to be refrigerated.  Eltroxin should be kept at room temperature below 25 degrees celsius.   Please note Eltroxin is not the same formula as Oroxine/Eutroxsig.  Please read information regarding Eltroxin on the Treatments page of this website.


  • Do not store Oroxine/Eutroxsig or any other medicines in a bathroom or near a sink.
  • Do not leave Oroxine/Eutroxsig in the car or on a window sill.

If tablets become soft, crumble, and/or discoloured, or you believe they are not effective, please contact:

The Australian Thyroid Foundation
e: info@thyroidfoundation.com.au  p: (02) 9890 6962


Aspen Pharmacare (Medical Affairs Department)
w: www.aspenpharmacare.com.au  p: 1300 659 646


Adverse Medicine Event Line
p: 1300 134 237



To ensure your medication stays cool and does not spoil from being exposed to heat whilst travelling, The ATF now has available as one of our many Member Services a Medication Travel Pack for members to purchase. The ATF is very pleased to announce, Aspen Pharmacare has provided sponsorship to allow The ATF to provide these much needed and requested Medication Travel Packs as a solution for ATF members to travel with their medication. The Medication Travel Pack is designed for transportation and cool storage of Oroxine and Eutroxsig.



  • Holds enough blister strips for an extended overseas trip of approximately 6 weeks depending on your dose
  • Secure strap to hold blisters in place
  • Will fit easily into carry on luggage to ensure it arrives with you and your medication is easily accessible to take whilst in transit
  • Download CMI about Oroxine and Eutroxsig

The ATF Medication Travel Pack is available to members of the ATF, as a Member Service. Join Today for thyroid one-on-one support, information and education. Once you're an ATF Member, login to your Membership Account to purchase a Medication Travel Pack.

ATF Medication Travel Pack

Members Can Purchase the ATF Medication Travel Pack for $39.00 + $10.00 Postage

After receiving many concerns from ATF Members about keeping Oroxine and Eutroxsig cool whilst travelling, The ATF Committee resourced The ATF Medication Travel Pack to include as one of our Members Services, for members of the ATF to purchase as a solution to travelling with Oroxine and Eutroxsig.


Become an ATF Member today and enjoy the many benefit of Membership, including the opportunity to purchase an ATF Medication Travel Pack. The ATF Medication Travel Pack is designed for transportation and cool storage of Thyroxine Replacement Hormone, (Oroxine and Eutroxsig). The Australian Thyroid Foundation recommend Oroxine and Eutroxsig should be stored in the refrigerator all of the time and not left out of the refrigerator for any reason. This is to avoid any possibility of spoilage, due to heat or light.

  • The Medication Travel Pack holds enough blister strips for an extended overseas trip of approximately 6 weeks, depending on your dose.
  • The Medication Travel Pack includes a secure strap to hold blister strips in place.
  • The Medication Travel Pack is to be placed in the freezer compartment of the refrigerator to freeze before use.
  • Once it is frozen, it will keep medication cool for an extended period of time without refrigeration. The Medication Travel Pack has a specifically designed inbuilt cooler system.


Member Tips For Medication Travel Pack


  • If you are travelling overseas using an airline, please note; no airlines will allow you to use on board refrigerators to store your medication whilst travelling.
  • A MTP measures approximately 24 x 12 x 5-1/2 cm and will fit comfortably into most handbags and carryon luggage.
  • To ensure your MTP arrives with you, never put your MTP in your check in luggage. You may also need to take your Oroxine/Eutroxsig whilst travelling.
  • Once you arrive at your destination, remove your Oroxine/Eutroxsig from the Medication Travel Pack and place in a refrigerator.
  • Place your Medication Travel Pack in a freezer to be ready for your return or continued journey.
  • If you are staying in hotel accommodation and you do not have a freezer in your room, ask Reception to freeze your Medication Travel Pack in the hotel freezer. If language is a problem, ask that it is placed with the ice cream and not the milk and ensure you say it has to be frozen hard.
  • The Medication Travel Pack comes in a drawstring pouch. Keep the drawstring pouch with your handbag or wallet to ensure you remember to remove your Oroxine/Eutroxsig from the refrigerator and retrieve your Medication Travel Pack from the hotel freezer before you leave.
  • Do not store your Oroxine/Eutroxsig blister strips in the freezer with your Medication Travel Pack. Your blister strips are to be refrigerated only.
  • It is a good idea to place a luggage label on your Medication Travel Pack zipper tag, with your contact details, in case you lose your Medication Travel Pack whilst travelling.


  • If it is more convenient for you to take your Oroxine/Eutroxsig before you get out of bed in the morning or because you take other prescribed medications that needs to be taken early in the morning, or with breakfast PLEASE NOTE: ATF members have recommended freezing the Medication Travel Pack during the day and cutting your daily dose of Oroxine/Eutroxsig off the blister, making sure the tablets are still in the blister foil and placing in the MTP before bedtime. Place the MTP on your bedside table with water, ready to take your Oroxine/Eutroxsig as soon as your eyes are open in the morning, or in the early hours.
  • Research states you should wait at least 4 hours after taking Oroxine/Eutroxsig before you take other medications.
  • A Medication Travel Pack is a great idea to use when having a Thyroid Pathology Test. It is recommended Thyroid Pathology Tests be done as early as possible in the morning and after fasting, before you take your Oroxine/Eutroxsig, (as soon as the pathologist opens in the morning). Take your Oroxine/Eutroxsig with you to the Pathologist in an MTP, with a bottle of water and take your Oroxine/Eutroxsig after the test is complete. Then wait at least 30-60 minutes before breakfast.

The Australian Thyroid Foundation (ATF) recommend The ATF Medication Travel Pack as an aid to control temperature of Thyroid Replacement Hormone, Oroxine and Eutroxsig for the specific time period if used correctly as per the included instruction sheet. However, to the extent permitted by law no warranty either implied or express, as to its efficiency is given by The ATF for individual use of the ATF Medication Travel Pack and the individual control of medication stored in the pack.

Our Mission

The mission of The Australian Thyroid Foundation Ltd (ATF) is to offer support, information and education to members and their families through the many services provided by The ATF and raise awareness about health consequences of iodine deficiency and the benefits of good thyroid health.

The ATF Medication Travel Pack is available to members of the organisation to purchase.

To become an ATF Member Get Started



  • Why has this medicine has been prescribed for you?
  • How long can you expect to stay on the medication?
  • Are there other future treatments you should consider?
  • Is this medication safe to take with other medications you are taking?
  • How often will you be monitored whilst taking the medication?
  • What side effects to I need to be aware of, whilst taking this medication?
  • If I experience side effects what should I do and who should I contact?
  • What do I need to know, if I want to consider pregnancy during my treatment? 


Treatment for Hyperthyroidism/OveractiveThyroid

Neo-Mercazole & Propylthiouracil (PTU) 


Your treating thyroid specialist will prescribe a dose of Neo-Mercazole or PTU to treat your condition and will monitor your thyroid response through pathology tests.

Things You Must Do Whilst Taking Neo-Mercazole

Ensure you inform all doctors, dentists and pharmacists who are treating you that you are taking Neo-Mercazole or PTU. Tell your treating thyroid specialist if you intend to become pregnant whilst taking the medication.

If you are referred to have laboratory testing of any kind, ensure you inform the doctor you are taking Neo-Mercazole or PTU.
If you believe the medication dose needs to be reviewed because your symptoms have changed, ensure you tell your treating thyroid specialist. Ensure you tell your treating thyroid specialist if you have missed a dose of the medication, especially before pathology testing. Ensure you keep appointments with your thyroid treating specialist and if you are concerned whilst taking the medication, ask for an appointment to discuss.

Whislt Taking Neo-Mercazole or PTU, Be Aware Of The Following Symptoms


  • Skin Rash
  • Fever
  • Severe Chills
  • Sore Throat
  • Mouth Ulcers
  • Tiredness, Lethagy
  • Muscle Weakness, cramps,
  • Feeling Cold
  • Hair Loss
  • Husky Voice
  • Unusual Weight Gain
  • Constipation
  • Headache

Contact Centre Details

Aspen Contact Centre

Phone: 1300 659 646 

Option 1: Medical and Safety enquiries (including Adverse Events) - medical@aspenpharmacare.com.au

Option 2: Quality Assurance (manufacturing and packaging complaints) - quality@aspenpharmacare.com.au

CLICK HERE to download the Aspen Contact Centre business card. 


If you develop any of these symptoms, or having any concerns whilst taking one of these medications, please contact your treating thyroid specialist immediately.

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